Antibiotic Comparison: How to Choose the Right Oral Antibiotic

If you or someone you know needs an antibiotic, the first question is usually “which one should I take?” The answer depends on the infection, the drug’s reach, side‑effects, and price. This guide breaks down the most common oral antibiotics so you can compare them side by side without a medical degree.

Key Factors to Weigh

Start with three basics: spectrum, dosage, and safety. Spectrum means how many types of bacteria the drug can kill – a broad‑spectrum antibiotic covers many bugs, while a narrow‑spectrum one targets just a few. Dosage covers how often you need to take the pill and for how many days. Safety is about common side‑effects and who should avoid the drug (kids, pregnant women, kidney patients, etc.).

Another practical factor is cost. Some brands are cheap generics, others are pricey brand‑name versions. Look at your insurance coverage and check reputable online pharmacies if you’re buying yourself. Finally, think about drug interactions – antibiotics can mess with blood thinners, birth‑control pills, or other meds you’re on.

Quick Look at Popular Antibiotics

Keflex (Cephalexin) – A first‑generation cephalosporin that works well for skin and soft‑tissue infections. Typical dose is 250‑500 mg every 6 hours for 7‑10 days. Side‑effects are mild: stomach upset, occasional rash. It’s inexpensive as a generic and safe for most adults.

Amoxicillin – The go‑to for ear, throat and sinus infections. Usually 500 mg three times a day. It’s narrow‑spectrum but covers many common bugs. Diarrhea is the most reported side‑effect. Cheap and widely available.

Azithromycin – A macrolide that stays in the body longer, so you often take it once daily for 3‑5 days. Good for respiratory infections and some sexually transmitted infections. Can cause stomach cramps and, rarely, heart rhythm changes. It’s pricier than amoxicillin but saves you from a long pill schedule.

Doxycycline – A tetracycline useful for acne, Lyme disease, and certain tick‑borne illnesses. Dose is 100 mg twice a day. Sun sensitivity and upset stomach are common. Not for pregnant women or kids under 8. Cost is moderate.

Levofloxacin – A fluoroquinolone with broad coverage, often reserved for tougher infections like complicated UTIs. Typical dose is 500 mg once daily for 5‑7 days. It can affect tendons and nerves, so doctors limit its use. It’s one of the more expensive options.

When you compare these drugs, match the infection type with the drug’s spectrum. For a simple skin boil, Cephalexin or Amoxicillin usually works. For a stubborn chest infection, a doctor might pick Azithromycin or a fluoroquinolone. Always let a healthcare provider confirm the choice.

To make an informed decision, write down the infection, any allergies, current meds, and your budget. Bring that list to the doctor or pharmacist. Ask specific questions: “How long will I need to take this?”, “What side‑effects should I watch for?”, and “Is a generic version available?”.

Remember, antibiotics only work against bacteria, not viruses. Using them for a cold or flu won’t help and can cause resistance. Finish the full course even if you feel better; stopping early lets surviving bacteria grow stronger.

With this antibiotic comparison guide, you now have a clear picture of the most common oral options. Use the factors above to compare, ask the right questions, and stay safe while treating bacterial infections.