Rheumatoid Arthritis: Causes, Treatments, and What You Need to Know

When your body turns on itself, that’s rheumatoid arthritis, a chronic autoimmune disease where the immune system mistakenly attacks the lining of your joints. Also known as RA, it’s not just aging joints or wear and tear—it’s an internal war that can affect your hands, knees, even your heart and lungs. Unlike osteoarthritis, which comes from physical breakdown, rheumatoid arthritis starts in your immune system. It doesn’t care if you’re 30 or 70—it can strike at any age, and women are two to three times more likely to get it than men.

This condition doesn’t just hurt. It swells, stiffens, and slowly destroys cartilage and bone. Over time, joints can deform, making simple tasks like opening a jar or buttoning a shirt hard. But here’s the thing: it’s not hopeless. Modern treatments don’t just mask pain—they slow or even stop the damage. immunosuppressants, drugs that calm down the overactive immune system like methotrexate or azathioprine (Imuran) are often the first line of defense. Biologics and JAK inhibitors came later, offering more targeted options for people who don’t respond to older meds. These aren’t quick fixes—they take weeks to work, and they need monitoring because they lower your body’s defenses. That’s why knowing what you’re taking, why you’re taking it, and what to watch for matters more than ever.

And it’s not just about pills. Rheumatoid arthritis connects to other things you might not realize. joint inflammation, the core problem in RA, is the same process seen in other autoimmune conditions like ulcerative colitis and Crohn’s disease. That’s why many people with RA also deal with gut issues, fatigue, or even eye problems. The inflammation doesn’t stay in one place. That’s also why telling your doctor about every supplement, herb, or OTC pain reliever you take is non-negotiable. Something as simple as turmeric or fish oil can interact with your meds—or mask symptoms that your doctor needs to see.

What you’ll find below isn’t a list of random articles. It’s a practical toolkit built by people who’ve been there. You’ll see how drugs like Imuran stack up against newer options, why heat can be dangerous if you’re on certain patches, how to avoid dangerous drug combos, and why managing your meds isn’t just about taking pills—it’s about understanding your body’s signals. Whether you’re newly diagnosed or have lived with RA for years, these posts cut through the noise and give you what actually works.

TNF Inhibitors: How Biologics Work for Autoimmune Conditions
17 November 2025 Andy Regan

TNF Inhibitors: How Biologics Work for Autoimmune Conditions

TNF inhibitors are biologic drugs that block tumor necrosis factor alpha to reduce inflammation in autoimmune diseases like rheumatoid arthritis and Crohn’s. They offer major symptom relief but carry infection risks and aren’t effective for everyone.

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